General Information

  • ID:  hor005776
  • Uniprot ID:  P08945
  • Protein name:  Litorin
  • Gene name:  NA
  • Organism:  Ranoidea aurea (Green and golden bell frog) (Litoria aurea)
  • Family:  Bombesin/neuromedin-B/ranatensin family
  • Source:  Animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:   Ranoidea (genus), Pelodryadinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda , Dipnotetrapodomorpha , Sarcopterygii (superclass), Euteleostomi , Teleostomi , Gnathostomata , Vertebrata , Craniata (subphylum), Chordata (phylum), Deuterostomia , Bilateria , Eumetazoa , Metazoa (kingdom), Opisthokonta , Eukaryota (superkingdom),cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QQWAVGHFM
  • Length:  9(1-9)
  • Propeptide:  QQWAVGHFM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T9 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005776_AF2.pdbhor005776_ESM.pdb

Physical Information

Mass: 124615 Formula: C51H70N14O12S
Absent amino acids: CDEIKLNPRSTY Common amino acids: Q
pI: 7.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 4
Hydrophobicity: -8.89 Boman Index: -129
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: -736.67 Extinction Coefficient cystines: 5500
Absorbance 280nm: 687.5

Literature

  • PubMed ID:  1140241
  • Title:  Aminoacid composition and sequence of litorin, a bombesin-like nonapeptide from the skin of the Australian leptodactylid frog Litoria aurea.
  • PubMed ID:  908397
  • Title:  Glu(OMe)3-litorin, the second bombesin-like peptide occurring in methanol extracts of the skin of the Australian